Philosophy of Experimental Biology explores some central philosophical issues concerning scientific research in experimental biology, including genetics, biochemistry, molecular biology, developmental biology, neurobiology, and microbiology. It seeks to make sense of the explanatory strategies, concepts, ways of reasoning, approaches to discovery and problem solving, tools, models and experimental systems deployed by scientific life science researchers and also integrates developments in historical scholarship, in particular the New Experimentalism. It concludes that historical explanations of scientific change that are based on local laboratory (...) practice need to be supplemented with an account of the epistemic norms and standards that are operative in science. This book should be of interest to philosophers and historians of science as well as to scientists. (shrink)

John Searle has argued that functions owe their existence to the value that we put into life and survival. In this paper, I will provide a critique of Searle’s argument concerning the ontology of functions. I rely on a standard analysis of functional predicates as relating not only a biological entity, an activity that constitutes the function of this entity and a type of system but also a goal state. A functional attribution without specification of such a goal state has (...) no truth-value. But if completed with a goal state, functional attributions understood as four-place relations attain a truth-value. The truth conditions of all attributions of function involve a dependence claim of the goal state on the function bearer’s activity. The nature of this dependence may differ; I consider five different possibilities: causality, mechanistic constitution, mereology, supervenience and metaphysical grounding. If these dependency relations are objective, Searle’s central ontological thesis fails. What he ought to have said is that our valuing survival or other goal states may be the reason why biology seeks functional knowledge, but this has nothing to do with ontology. I will show further that Searle also raised an interesting challenge concerning the relationship of functional and causal truths, but it does not threaten the objectivity of functions either. At best, it could show that functional vocabulary is eliminable. However, I will show that functional vocabulary is not so eliminable. (shrink)

This paper suggests that certain traditional ways of analysing the self start off in situations that are abstract or detached from normal experience, and that the conclusions reached in such approaches are, as a result, inexact or mistaken. The paper raises the question of whether there are more contextualized forms of self-consciousness than those usually appealed to in philosophical or psychological analyses, and whether they can be the basis for a more adequate theoretical approach to the self. First, we develop (...) a distinction between abstract and contextualized actions and intentions by drawing on evidence from studies of rehabilitation after brain damage, and we introduce the notion of intentional attitude. Second, we discuss several interesting conclusions drawn from theoretically and experimentally abstract approaches. These conclusions raise some important issues about both the nature of the self and reflexive consciousness. At the same time they indicate the serious limitations concerning what we can claim about self and self-consciousness within such abstract frameworks. Such limitations motivate the question of whether it is possible to capture a sense of self that is more embedded in contextualized actions. Specifically, our concern is to focus on first-person approaches. We identify two forms of self-consciousness, ecological self-awareness and embedded reflection, that function within the kinds of contextualized activity we have indicated, and can be the basis for a theoretical account of the self. Both forms of self-consciousness are closely tied to action and promise to provide a less abstract basis for developing a theoretical approach to the self. (shrink)

The present study explores the contribution of the Slovak philosophical school, which uniquely grasped the European and Czechoslovak heritage of phenomenology and existential philosophy. In the text, the authors present a congenial and undeniably up-to-date concept of syncriticism as developed by Jozef Piaček and analyse its contribution to Slovak philosophical discourse and more broadly, in the dialogue of phenomenology and existential philosophy in Slovakia. In the study, the authors also examine the cultural-philosophical starting points and specifics of Slovak modern philosophy (...) and postmodern thinking as phenomena of the Central European intellectual space in the context of thinking about the unique and inspiring project of perichronosophy as a thematic invariant developed at philosophical workplaces in Central Europe (Comenius University Bratislava, Trnava University Trnava, Charles University Prague, Masaryk University Brno). Jozef Piaček has been affiliated with the Faculty of Arts, Comenius University for many years, studied under Jan Patočka and is an expert on Husserl’s phenomenology. He has continuously developed a unique philosophical approach involving syncriticism and perichronosophy, which continues to resonate with his students at academic institutions in Slovakia and abroad. Piaček published several monographs and papers on the subject of syncriticism. The platform of living philosophy is his concept of a digital philosophical encyclopaedia, where he archives all publication outputs on the subject of the philosophy of syncriticism. This text will present Piaček’s concept of perichronosophy and concordance in Slovak philosophy, more broadly in phenomenology, as well as in the context of Patočka’s themes (philosophy as care for the soul in the village) with implications for the philosophy of education and philosophical therapy (dasein-analysis). (shrink)

Biological modalities, i.e., biologically possible, impossible, or necessary states of affairs have not received much attention from philosophers. Yet, it is widely agreed that there are biological constraints on physically possible states of affairs, such that not everything that is physically possible is also biologically possible, even if everything that is biologically possible is also physically possible. Furthermore, biologists use concepts that appear to be modal in nature, such as the concept of evolvability in evolutionary developmental biology, or “evo-devo.” The (...) present chapter investigates what kind of modality underlies the concept of evolvability. This concept tries to capture the capacity of an organism or a lineage to sustain genetic changes that enable it to evolve or to evolve adaptively. The basic idea of the proposed approach is to construe evolvability as a kind of accessibility in a modal space. The difficult part is to specify this modal space and the relevant accessibility relation. While there may not be a general way of defining such a relation, there exist model systems for which it is possible, e.g., evolving small RNAs. The modal space in such cases turns out to be quite distinct from those constructed by philosophers, e.g., David Lewis’s similarity metric for possible worlds. Even though the biological case examined here is quite special, attending to the way in which biological possibilities are modeled in this case harbors some general lessons about biological modalities, in particular their dependence on the explanatory goals of the models modeling modality. (shrink)

This is an agenda-setting exploration of the relationship between green politics and liberal ideology. Ecological problems provide unique challenges for liberal democracies.; This challenge is examined by the author who aims to fill the gap between short-term ecological modernization and the politically infeasible longer term utopian approaches.

The recent literature on causality has seen the introduction of several distinctions within causality, which are thought to be important for understanding the widespread scientific practice of focusing causal explanations on a subset of the factors that are causally relevant for a phenomenon. Concepts used to draw such distinctions include, among others, stability, specificity, proportionality, or actual-difference making. In this contribution, I propose a new distinction that picks out an explanatorily salient class of causes in biological systems. Some select causes (...) in complex biological systems, I argue, have the property of enabling coherent causal control of these systems. Examples of such control variables include hormones and other signaling molecules, e.g., TOR (target of rapamycin), morphogens or the products of homeotic selector genes in embryonic pattern formation. I propose an analysis of this notion based on concepts borrowed from causal graph theory. (shrink)

For contagious diseases like measles a successful immunization program can result in herd protection. Small outbreaks may still occur but fade out soon, because the possibilities for the pathogen to spread in the ‘herd’ are very small. This implies that people who refuse to participate in such a program will still benefit from the protection it offers, but they don’t do their part in maintaining protection. Isn’t that a case of freeriding—and isn’t that unfair towards all the people who do (...) collaborate? If so, that might be considered an additional ground for making vaccination mandatory or compulsory.In this paper I argue that vaccination refusal can be considered as freeriding, but that this might not be unfair. The public good of herd protection is a peculiar public good because it supervenes on private benefits that are enjoyed by all who do opt for vaccination. For vaccinated individuals, the additional benefit of herd protection comes about, as it were, for free, and hence they can’t complain that others benefit without sharing in the burdens. There are however still other grounds for making vaccination compulsory or at least for seeing refusal as a morally wrong choice. (shrink)

Environmental pollution and greenhouse gas emissions that contribute to climate change have adverse impacts on global health. Somewhat paradoxically, health care systems that aim to prevent and cure disease are themselves major emitters and polluters. In this paper we develop a justification for the claim that solidaristic health care systems should include sustainability as one of the criteria for determining which health interventions are made available or reimbursed – and which not. There is however a complication: most adverse health effects (...) due to climate change do occur elsewhere in the world. If solidarity would commit us to take care of everyone’s health, worldwide, it might imply that solidaristic health system cannot justifiably restrict universal access to their own national populations. In response we explain health solidarity is to be considered as a moral ideal. Such an ideal does not specify what societies owe to whom, but it does have moral implications. We argue that ignoring sustainability in political decision making about what health care is to be offered, would amount to betrayal of the ideal of solidarity. (shrink)

One of the societal problems in a new influenza pandemic will be how to use the scarce medical resources that are available for prevention and treatment, and what medical, epidemiological and ethical justifications can be given for the choices that have to be made. Many things may become scarce: personal protective equipment, antiviral drugs, hospital beds, mechanical ventilation, vaccination, etc. In this paper I discuss two general ethical principles for priority setting (utility and equity) and explain how these principles will (...) often point in diverging directions. Moreover, each of these principles can be understood in different, again often competing, ways. Notwithstanding these controversies and conflicts, in the context of pandemic response there are at least some points of convergence: several policies can be justified by appeal to different ethical principles and theories. Convergence may be found with respect to a focus on saving the most lives (instead of other aggregative accounts); giving priority antiviral prophylaxis and therapy for life-saving pandemic responders; and, partly depending on epidemiology of the pandemic, to prioritise vaccination of children. Although decision-making about access to intensive care will involve choices with immediate tragic implications, the ethical complexity of these choices is relatively modest (although decisions will not be easy): there are persuasive moral reasons for giving priority to patients who are expected to benefit most within the shortest time. Finally, in the last section I tentatively argue that constraints on people’s freedom, as necessary for an effective public health approach, may support giving somewhat more weight to saving the most lives, than to concerns of equity. (shrink)

Recently, there has been an effort to make libertarianism compatible with a redistributive inheritance tax: When the tax is levied, the taxpayer in question is already dead and as such she cannot be a bearer of rights. The state is therefore allowed to redistribute the (value of) the estate according to some distributive principle. I consider (and finally dismiss) four successive arguments, each concluding that the state is allowed to use the estate for redistributive purposes. I show that neither of (...) them is able to reconcile (right-) libertarianism with a redistributive inheritance tax. Instead of trying to square the circle, proponents of such a tax should meet the theoretical essentials of (right-) libertarianism head-on. (shrink)

" Notre époque est celle de la prise de conscience de l'unité humaine. Dès lors, il est temps que la philosophie accomplisse sa vocation à l'universalité. Comme la nature est cela seul qui s'offre avec évidence à tous les hommes, une philosophie œcuménique ne peut être qu'une philosophie de la Nature. Or, si l'on lit le Tao-te king avec, en pensée, la philosophie naturaliste des Grecs d'avant Socrate, celle, en particulier, d'Héraclite, on se trouve en pays familier, et l'on vérifie (...) que les mêmes évidences essentielles s'imposent à tous les humains, à tous ceux du moins capables d'appréhender la Nature dans l'Ouvert. " M.C. (shrink)

This paper describes a computer simulation of reading that is strongly driven by eye fixation data from human readers. The simulation, READER, is a natural language understanding system that reads a text word by word and whose processing cycles on each word have some correspondence with the human gaze duration on that word. READER operates within a newly developed information processing architecture, a Collaborative, Activation‐based, Production System (CAPS) that permits the modeling of the temporal properties of human comprehension. CAPS allows (...) for concurrent, collaborative execution of processes operating at different levels of analysis. As READER encounters each successive word, the word is operated on by processes at the levels of word encoding, lexical access, syntactic and semantic analysis, and referential and schema‐level processes. Like human readers, READER uses a strategy of immediacy of comprehension, attempting to interpret each word as soon as it is encountered, rather than unnecessarily buffering information. A major contribution of this simulation is its use of human performance characteristics in constraining and determining the model's mechanisms. (shrink)

Many nursing homes have an influenza vaccination policy in which it is assumed that express (proxy) consent is not necessary. Tacit consent procedures are more efficient if one aims at high vaccination rates. In this paper I focus on incompetent residents and proxy consent. Tacit proxy consent for vaccination implies a deviance of standard proxy consent requirements. I analyse several arguments that may possibly support such a deviance. The primary reason to offer influenza vaccination is that vaccinated persons have a (...) significantly reduced risk of getting the flu. This reason however cannot support the assumption that each nursing home resident is ‘better off ’ if she is vaccinated. Neither can it support tacit proxy consent policies. More promising are arguments that take the collective nature of infectious diseases into account. A potentially strong, but ultimately insufficient, argument for non‐express consent is that vaccination contributes to prevention of harm to others. Other arguments emphasise the importance of group protection: herd immunity. I discuss three collective reasons for aiming at herd immunity: solidarity, a common interest in reducing the risk of illness, and a common interest in the prevention of an influenza outbreak. The latter argument appears to be most important. An outbreak is not just detrimental to the health of residents; it is detrimental to their everyday social life as well. Outbreaks can be seen as a collective evil. My analysis shows that there are valid (though not necessarily sufficient) moral arguments for a tacit proxy consent policy. (shrink)

Several authors have used the notion of causal specificity in order to defend non-parity about genetic causes (Waters 2007, Woodward 2010, Weber 2017, forthcoming). Non-parity in this context is the idea that DNA and some other biomolecules that are often described as information-bearers by biologists play a unique role in life processes, an idea that has been challenged by Developmental Systems Theory (e.g., Oyama 2000). Indeed, it has proven to be quite difficult to state clearly what the alleged special role (...) of genetic causes consists in. In this paper, I show that the set of biomolecules that are normally considered to be information-bearers (DNA, mRNA) can be shown to be the most specific causes of protein primary structure, provided that causal specificity is measured over a relevant space of biological possibilities, disregarding physical as well as logically possible states of the causal variables. (shrink)

Control measures directed at carriers of multidrug-resistant organisms are traditionally approached as a trade-off between public interests on the one hand and individual autonomy on the other. We propose to reframe the ethical issue and consider control measures directed at carriers an issue of solidarity. Rather than asking “whether it is justified to impose strict measures”, we propose asking “how to best care for a person’s carriership and well-being in ways that do not imply an unacceptable risk for others?”. A (...) solidarity approach could include elevating baseline levels of precaution measures and accepting certain risks in cases where there is exceptionally much at stake. A generous national compensation policy that also covers for costs related to dedicated care is essential in a solidarity approach. An additional benefit of reframing the questions is that it helps to better acknowledge that being subjected to control measures is a highly personal matter. (shrink)

Cet ouvrage est une réédition numérique d’un livre paru au XXe siècle, désormais indisponible dans son format d’origine.

The aim of this book is to foster a more explicit and direct discussion of the concept of sacrifice and its importance in moral philosophy. Acts of self-sacrifice have a special place in our moral lives. We admire and celebrate those who give up their lives so that others may live. Despite this important role that sacrifice plays in our moral thinking, moral philosophers have had surprisingly little to say about the nature of sacrifice. This lack of attention to the (...) nature of sacrifice is particularly important given that sacrifice also has an important role to play in several key debates in moral philosophy. The chapters in this volume make an important contribution to our understanding of sacrifice in three areas. The first part of the book investigates the nature of sacrifice. The next group of chapters investigates the role of sacrifice in moral philosophy. Three of these pieces investigate the role of sacrifice in our moral lives generally, while two investigate the role of sacrifice in relation to particular moral theories. The final two chapters investigate the value of sacrifice in relation to political and theological issues. The chapters in this book were originally published as a special issue of the International Journal of Philosophical Studies. (shrink)

Darwin famously held that his use of the term "chance" in evolutionary theory merely "serves to acknowledge plainly our ignorance of the causes of each particular variation". Is this a tenable view today? Or should we revise our thinking about chance in evolution in light of the more advanced, quantitative models of Neo-Darwinian theory, which make substantial use of statistical reasoning and the concept of probability? Is determinism still a viable metaphysical doctrine about biological reality after the quantum revolution in (...) physics, or dowe have to abandon it in favor of an objective indeterminism? In light of such reflections, what is the relevant interpretation of probability in evolutionary theory? Do biologists use the concept of probability because they are finite cognitive agents or because the evolutionary process is fundamentally probabilistic? In this paper, I will show that we do not yet fully understand the nature of chance in evolution. (shrink)

Ecological thought has made a deep and apparently lasting impact on virtually every tradition in political theory (cf. e.g. Dobson, 2007) with the exception of libertarianism. While left- and right...

Enzyme directed genetic mechanisms causing random DNA sequence alterations are ubiquitous in both eukaryotes and prokaryotes. A number of molecular geneticist have invoked adaptation through natural selection to account for this fact, however, alternative explanations have also flourished. The population geneticist G.C. Williams has dismissed the possibility of selection for mutator activity on a priori grounds. In this paper, I attempt a refutation of Williams' argument. In addition, I discuss some conceptual problems related to recent claims made by microbiologists on (...) the adaptiveness of molecular variety generators in the evolution of prokaryotes. A distinction is proposed between selection for mutations caused by a mutator activity and selection for the mutator activity proper. The latter requires a concept of fitness different from the one commonly used in microbiology. (shrink)

Causal selection is the task of picking out, from a field of known causally relevant factors, some factors as elements of an explanation. The Causal Parity Thesis in the philosophy of biology challenges the usual ways of making such selections among different causes operating in a developing organism. The main target of this thesis is usually gene centrism, the doctrine that genes play some special role in ontogeny, which is often described in terms of information-bearing or programming. This paper is (...) concerned with the attempt of confronting the challenge coming from the Causal Parity Thesis by offering principles of causal selection that are spelled out in terms of an explicit philosophical account of causation, namely an interventionist account. I show that two such accounts that have been developed, although they contain important insights about causation in biology, nonetheless fail to provide an adequate reply to the Causal Parity challenge: Ken Waters's account of actual-difference making and Jim Woodward's account of causal specificity. A combination of the two also doesn't do the trick, nor does Laura Franklin-Hall's account of explanation (in this volume). We need additional conceptual resources. I argue that the resources we need consist in a special class of counterfactual conditionals, namely counterfactuals the antecedents of which describe biologically normal interventions. (shrink)

(No abstract is available for this citation).

Édition d'un nouveau fragment de la dédicace d'Hadrien SEG XI 340. Elle avait trait à la réfection d'un des temples urbains d'Héra, détruit par un incendie.

1. La soif de la sagesse -- 2. La révélation de la sagesse.

Un moment heureux de ma vie furent ces journées de mai 2012 où mes amis Jean-Philippe Catonné, André Comte-Sponville, Françoise Dastur, Gilbert Kirscher et Yvon Quiniou sont venus à "La Maison-neuve" pour débattre de ma philosophie. J'admire la profonde compréhension qu'ils ont montrée, de ma façon de voir les choses, bien qu'ayant la leur propre. Ils ont leurs philosophies et j'espère que ces Entretiens inciteront les lecteurs à se tourner vers elles autant que vers la mienne. Mon "scepticisme à l'intention (...) d'autrui" me permet de concilier la certitude que j'ai avec l'existence d'autres pensées philosophiquement cohérentes. (shrink)

Peut-on dire qu'une philosophie est vraie?" [et la réponse négative de Canguilhem], "La réalité des philosophies" [et l'idéalisme radical de Gueroult], "Les deux systèmes de métaphysique" [et la place de Spinoza], "Comment je vois la Nature", "Les points cardinaux de ma philosophie", "Comment philosopher", "Faire son devoir" [ce qui compte est 1'k-te] sont parmi les chapitres principaux de cet ouvrage. Ceux-ci sont secondaires : "Bergson et Eucken", "Palmyre", "Kant contre Spinoza" [sur la place des définitions]."--Page 4 of cover.

M Conche met l'accent sur certaines distinctions qui lui semblent essentielles pour appréhender sa philosophie : conscience et pensée, argument et preuve, cause et raison, infini et indéfini, monde et univers, univers et nature, science et métaphysique, etc. Il aborde également d'autres sujets comme la solitude, l'animalité, Descartes au secours de la religion ou Socrate et les dieux.